Gan to kagaku ryoho. Cancer & chemotherapy · 2021
[A Case of Colon Cancer with Suspected DPD Deficiency Causing Severe Adverse Effects following Adjuvant Chemotherapy with Capecitabine].
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Nagahisa Seiichi, Watanabe Megumi, Minagi Hitoshi, Ogawa Toshihiro, Araki Hiroyuki, Kimura Yuji, Taniguchi Fumitaka, Arata Takashi, Katsuda Ko, Tanakaya Koji, Aoki Hideki
Аннотация
The present study reports a case of colon cancer in a 76-year-old female who underwent laparoscopic right colectomy. Pathological findings revealed pT3(SS), pN2a, cM0, and pStage Ⅲb. Hence, we administered adjuvant chemotherapy with capecitabine. On day 18, she was urgently hospitalized because of severe oral mucositis(grade 3), diarrhea(grade 3), and leukocytopenia(grade 4). Furthermore, the patient experienced DIC, which gradually improved through intensive conservative treatment. From the clinical course, we suspected that the severe adverse effects were caused due to a deficiency of DPD. We were able to save the patient through early treatment.