Multiple sclerosis and neuromyelitis optica spectrum disorders in Argentina: comparing baseline data from the Argentinean MS Registry (RelevarEM).
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rojas Juan Ignacio, Alonso Serena Marina, Garcea Orlando, Patrucco Liliana, Carrá Adriana, Correale Jorge, Vrech Carlos, Pappolla Agustín, Miguez Jimena, Doldan María L, Silveira Facundo, Alonso Ricardo, Cohen Leila, Pita Cecilia, Silva Berenice A, Fiol Marcela, Gaitán María I, Marrodan Mariano, Negrotto Laura, Ysrraelit María C, Deri Norma, Luetic Geraldine, Caride Alejandro, Carnero Contentti Edgar, Lopez Pablo A, Pettinicchi Juan Pablo, Curbelo Celeste, Martinez Alejandra D, Steinberg Judith D, Balbuena María E, Tkachuk Verónica, Burgos Marcos, Knorre Eduardo, Leguizamon Felisa, Piedrabuena Raúl, Liwacki Susana Del V, Barboza Andrés G, Nofal Pedro, Volman Gabriel, Alvez Pinheiro Amelia, Hryb Javier, Tavolini Dario, Blaya Patricio A, Silva Emanuel, Blanche Jorge, Tizio Santiago, Caceres Fernando, Saladino María Laura, Zanga Gisela, Fracaro María E, Sgrilli Gustavo, Pagani Cassara Fátima, Vazquez Guido, Sinay Vladimiro, Menichini María Laura, Lazaro Luciana, Cabrera Lorena M, Bestoso Santiago, Divi Pablo, Jacobo Miguel, Kohler Eduardo, Kohler Matías, Giunta Diego, Mainella Carolina, Manzi Ruben, Parada Marcilla Marcela, Viglione Juan Pablo, Martos Ivan, Reich Edgardo, Jose Gustavo, Cristiano Edgardo, Fernández Liguori Nora, on behalf RelevarEM investigators
Аннотация
METHODS: RelevarEM is a longitudinal, strictly observational MS and NMOSD registry in Argentina. Epidemiological and comorbidity data from MS and NMOSD patients were described and compared. For comorbidities, the Charlson comorbidity index (CCI) was used to calculate the burden at entry. CCI was stratified in 0 and ≥ 1 and described for the entire cohort.
RESULTS: A total of 1588 and 75 MS and NMOSD patients (respectively) were included. For MS patients, the mean age was 42 ± 7 years, female sex 65.3%, mean EDSS 2, and mean disease duration 8 ± 6 years. In NMOSD, the mean age was 40 ± 7 years, female sex 78.7%, mean disease duration 5 ± 3.5 years, and mean EDSS 2.5. The most frequent MS phenotype was RRMS in 82.4%. In MS, the CCI was 0 in 85.8.2% while ≥ 1 was in 14.2% of patients. Regarding phenotype stratification, CCI ≥ 1 was 3.9% in CIS, 13.5% in RRMS, 28.7% in SPMS, and 17.4% in PPMS (p < 0.001 between groups). In NMOSD, the CCI was 0 in 64% while ≥ 1 was in 36%. The MS/NMOSD ratio found was 21/1.
CONCLUSIONS: This is the first analysis of the longitudinal Argentinean registry of MS and NMOSD describing and comparing conditions that contributes to provide reliable real-world data in the country.