Characteristics and treatment of Multiple Sclerosis-related trigeminal neuralgia: An Italian multi-centre study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Ferraro Diana, Annovazzi Pietro, Moccia Marcello, Lanzillo Roberta, De Luca Giovanna, Nociti Viviana, Fantozzi Roberta, Paolicelli Damiano, Ragonese Paolo, Gajofatto Alberto, Boffa Laura, Cavalla Paola, Lo Fermo Salvatore, Buscarinu Maria Chiara, Lorefice Lorena, Cordioli Cinzia, Calabrese Massimiliano, Gallo Antonio, Pinardi Federica, Tortorella Carla, Di Filippo Massimiliano, Camera Valentina, Maniscalco Giorgia Teresa, Radaelli Marta, Buttari Fabio, Tomassini Valentina, Cocco Eleonora, Gasperini Claudio, Solaro Claudio, RIREMS (Rising Researchers in Multiple Sclerosis)
Аннотация
METHODS: Neurologists members of the RIREMS group (Rising Researchers in MS) enrolled MS patients with a TN diagnosis and filled out a spreadsheet comprising their clinical data.
RESULTS: Population consisted of 298 patients. First-choice preventive treatments were carbamazepine and oxcarbazepine. A surgical procedure was performed in 81 (30%) patients, most commonly gamma knife stereotactic radiosurgery (37%), followed by microvascular decompression (22%) and radiofrequency thermocoagulation (21%); one third of patients underwent at least two procedures. Surgery was associated with higher disability, male sex and longer interval between MS and TN onset. Patients (77%) who stayed on at least one preventive medication at most recent follow-up, after a mean period of 8 years, had a higher disability compared to the untreated group. Furthermore, patients with higher disability at TN onset were less likely to discontinue their first preventive medication due to pain remission, had bilateral TN more frequently and underwent surgical interventions earlier.
CONCLUSION: MS patients with a higher disability at TN onset and with a longer interval between MS and TN onset had differing clinical features and outcomes: pain was more frequently bilateral, surgery was more frequent and anticipated, and preventive medication discontinuation due to pain remission was less common.