Amebic liver abscess with bronchopleural fistula.

Amebic liver abscess with bronchopleural fistula caused by Entamoeba histolytica can mimic severe bacterial sepsis in a returning traveller. Rapid diagnosis via multiplex Polymerase Chain Reaction (PCR) on abscess fluid enabled targeted therapy within 24 h, avoiding unnecessary broad-spectrum antibiotics. Intestinal amebiasis should be considered in patients with compatible symptoms and relevant exposure.