Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.
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VandeBunte Anna M, Lee Hyunwoo, Paolillo Emily W, Hsiung Ging-Yuek Robin, Staffaroni Adam M, Saloner Rowan, Tartaglia Carmela, Yaffe Kristine, Knopman David S, Ramos Eliana Marisa, Rascovsky Katya, Bozoki Andrea C, Wong Bonnie, Domoto-Reilly Kimiko, Snyder Allison, Pressman Peter, Mendez Mario F, Litvan Irene, Fields Julie A, Galasko Douglas R, Darby Ryan, Masdeu Joseph C, Pasqual Maria Belen, Honig Lawrence S, Ghoshal Nupur, Appleby Brian S, Mackenzie Ian R, Heuer Hilary W, Kramer Joel H, Boxer Adam L, Forsberg Leah K, Boeve Brad, Rosen Howard J, Casaletto Kaitlin B, ALLFTD Consortium
Аннотация
METHODS: Two hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.
RESULTS: Among variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories.
DISCUSSION: Better baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD.
HIGHLIGHTS: Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.