Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.
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Reddy Joseph S, Heath Laura, Linden Abby Vander, Allen Mariet, Lopes Katia de Paiva, Seifar Fatemeh, Wang Erming, Ma Yiyi, Poehlman William L, Quicksall Zachary S, Runnels Alexi, Wang Yanling, Duong Duc M, Yin Luming, Xu Kaiming, Modeste Erica S, Shantaraman Anantharaman, Dammer Eric B, Ping Lingyan, Oatman Stephanie R, Scanlan Jo, Ho Charlotte, Carrasquillo Minerva M, Atik Merve, Yepez Geovanna, Mitchell Adriana O, Nguyen Thuy T, Chen Xianfeng, Marquez David X, Reddy Hasini, Xiao Harrison, Seshadri Sudha, Mayeux Richard, Prokop Stefan, Lee Edward B, Serrano Geidy E, Beach Thomas G, Teich Andrew F, Haroutunian Varham, Fox Edward J, Gearing Marla, Wingo Aliza, Wingo Thomas, Lah James J, Levey Allan I, Dickson Dennis W, Barnes Lisa L, De Jager Philip, Zhang Bin, Bennett David, Seyfried Nicholas T, Greenwood Anna K, Ertekin-Taner Nilüfer
Аннотация
METHODS: To bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.
RESULTS: We generated multi-omics data and curated and harmonized phenotypic data from BA (n = 306), LA (n = 326), or BA and LA (n = 4) brain donors plus non-Hispanic White (n = 252) and other (n = 20) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures.
DISCUSSION: The inclusion of traditionally underrepresented groups in multi-omics studies is essential to discovering the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.
HIGHLIGHTS: Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.