Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
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Leuzy Antoine, Raket Lars Lau, Villemagne Victor L, Klein Gregory, Tonietto Matteo, Olafson Emily, Baker Suzanne, Saad Ziad S, Bullich Santiago, Lopresti Brian, Bohorquez Sandra Sanabria, Boada Mercè, Betthauser Tobey J, Charil Arnaud, Collins Emily C, Collins Jessica A, Cullen Nicholas, Gunn Roger N, Higuchi Makoto, Hostetler Eric, Hutchison R Matthew, Iaccarino Leonardo, Insel Philip S, Irizarry Michael C, Jack Clifford R, Jagust William J, Johnson Keith A, Johnson Sterling C, Karten Yashmin, Marquié Marta, Mathotaarachchi Sulantha, Mintun Mark A, Ossenkoppele Rik, Pappas Ioannis, Petersen Ronald C, Rabinovici Gil D, Rosa-Neto Pedro, Schwarz Christopher G, Smith Ruben, Stephens Andrew W, Whittington Alex, Carrillo Maria C, Pontecorvo Michael J, Haeberlein Samantha Budd, Dunn Billy, Kolb Hartmuth C, Sivakumaran Sudhir, Rowe Christopher C, Hansson Oskar, Doré Vincent
Аннотация
METHODS: Using head-to-head data from five cohorts with tau PET radiotracers designed to target tau deposition in AD, we tested a joint propagation model (JPM) to harmonize quantification (units termed "CenTauR" [CTR]). JPM is a statistical model that simultaneously models the relationships between head-to-head and anchor point data. JPM was compared to a linear regression approach analogous to the one used in the amyloid PET Centiloid scale.
RESULTS: A strong linear relationship was observed between CTR values across brain regions. Using the JPM approach, CTR estimates were similar to, but more accurate than, those derived using the linear regression approach.
DISCUSSION: Preliminary findings using the JPM support the development and adoption of a universal scale for tau-PET quantification.
HIGHLIGHTS: Tested a novel joint propagation model (JPM) to harmonize quantification of tau PET. Units of common scale are termed "CenTauRs". Tested a Centiloid-like linear regression approach. Using five cohorts with head-to-head tau PET, JPM outperformed linearregressionbased approach. Strong linear relationship was observed between CenTauRs values across brain regions.