Pediatric obesity · 2024
Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Sewaybricker Leticia E, Melhorn Susan J, Entringer Sonja, Buss Claudia, Wadhwa Pathik D, Schur Ellen A, Rasmussen Jerod M
Аннотация
BACKGROUND: The mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2-based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity.
OBJECTIVES/METHODS: The current study aimed to extend this concept to the early life period by considering if, in full-term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.
RESULTS: In this initial study, neonatal T2 signal in the MBH was positively associated with six-month changes in body fat percentage.
CONCLUSION: This finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.
OBJECTIVES/METHODS: The current study aimed to extend this concept to the early life period by considering if, in full-term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.
RESULTS: In this initial study, neonatal T2 signal in the MBH was positively associated with six-month changes in body fat percentage.
CONCLUSION: This finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.