Ocular immunology and inflammation · 2018
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Caputo Roberto, Pasti Mattia, de Libero Cinzia, Mori Francesca, Barni Simona, Danti Gioia, Buonvicino Daniela, Urru Matteo, Chiarugi Alberto, Pucci Neri
Аннотация
Purpose: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. Methods: Tear fluids was collected in a group of VKC patients and compared to a control group of healthy subjects. HMGB1 concentration was measured using the HMGB1 ELISA II test both in VCK and control subjects. Results: The mean concentration of HMGB1 in tear fluids of 45 VKC patients was 0,977 ± 0,72 ng/ml whereas in the control group was 0,24 ± 0,25 ng/ml and the difference was statistically significant (p = 0,000106) Conclusion: The concentration of HMGB1 in VCK patients was found to be significantly increased, suggesting a possible role of this protein in the inflammatory mechanism of VKC.