Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023
A case of drug-induced organizing pneumonia caused by amikacin liposome inhalation suspension.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Takao Daisuke, Takeda Kazuaki, Takazono Takahiro, Ozasa Mutsumi, Ito Yuya, Ashizawa Nobuyuki, Hirayama Tatsuro, Iwanaga Naoki, Takemoto Shinnosuke, Ide Shotaro, Tashiro Masato, Hosogaya Naoki, Kido Takashi, Sakamoto Noriho, Obase Yasushi, Okano Shinji, Izumikawa Koichi, Yanagihara Katsunori, Mukae Hiroshi
Аннотация
Inhaled liposomal antimicrobials are known to cause hypersensitivity pneumonitis. Amikacin liposome inhalation suspension (ALIS) is a promising novel antimicrobial agent against refractory Mycobacterium avium complex infections. The frequency of drug-induced lung injury caused by ALIS is relatively high. To date, no reports of ALIS-induced organizing pneumonia diagnosed by bronchoscopy are available. We report a case of a 74-year-old female patient presenting with non-tuberculous mycobacterial pulmonary disease (NTM-PD). She was treated with ALIS for refractory NTM-PD. Fifty-nine days after starting ALIS, the patient developed a cough, and her chest radiographs indicated deterioration. She was diagnosed with organizing pneumonia based on pathological findings of the lung tissues obtained by bronchoscopy. After switching from ALIS to amikacin infusion, her organizing pneumonia improved. It is difficult to distinguish between organizing pneumonia and an exacerbation of NTM-PD based on chest radiography alone. Therefore, it is essential to perform an active bronchoscopy for diagnosis.