Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2013
Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ikeda Masaki, Yonemura Kimie, Kakuda Satoko, Tashiro Yuichi, Fujita Yukio, Takai Eriko, Hashimoto Yukiko, Makioka Kouki, Furuta Natsumi, Ishiguro Koichi, Maruki Risa, Yoshida Jun'ichi, Miyaguchi Osamu, Tsukie Tamao, Kuwano Ryouzou, Yamazaki Tsuneo, Yamaguchi Haruyasu, Amari Masakuni, Takatama Masamitsu, Harigaya Yasuo, Okamoto Koichi
Аннотация
We studied seven cases of Alzheimer's disease (AD). Six of the patients had presenilin 1 (PS1) mutations (PS1AD). Three novel PS1 mutations (T99A, H131R and L219R) and three other missense mutations (M233L, H163R and V272A) were found in the PS1AD group. We measured the levels of phosphorylated tau (ptau-181, ptau-199) and Aβ (Aβ1-42, Aβ1-40 and Aβ1-38) in the cerebrospinal fluid (CSF) of PS1AD patients, early-onset sporadic AD (EOSAD), late-onset sporadic AD (LOSAD) and non-demented subjects (ND). The CSF levels of Aβ1-42 in the three AD groups were significantly lower than those of the ND group (p < 0.0001). CSF levels of Aβ1-42 in the PS1AD group were significantly lower than those in the two sporadic AD groups. The Aβ1-40 and Aβ1-38 levels in the CSF of the PS1AD group were significantly lower than those of the three other groups (p < 0.0001, respectively). The levels of Aβ1-40, Aβ1-38 and Aβ1-42 in the CSF of the PS1AD group remained lower than those of the ND group for 4 years. Not only CSF Aβ1-42, but also Aβ1-40 and Aβ1-38 decreased in the advanced stages of PS1AD.