Journal of medical virology · 2026
Enterovirus D68 Epidemic in Children With Acute Respiratory Infections in Beijing, China, 2017-2024.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fu Hanhaoyu, De Ri, Han Zhenzhi, Jia Liping, Zhu Runan, Sun Yu, Chen Dong-Mei, Zhou Yutong, Guo Qi, Yao Yao, Wang Fangming, Zhu Chunmei, Zhao Linqing
Аннотация
The increased circulation of enteroviruses (EVs) from July to December 2024 necessitated a retrospective analysis of hospitalized children with acute respiratory infections in Beijing, China, during 2017-2024. Among the 155 cases confirmed as EVs (0.67%, 155/23,245), with peaks in a triennial pattern and predominance between July and October, 114 were EV-D68, with 82 (71.93%) detected between July and October 2024. Among the 79 VP1 gene sequences of EV-D68 classified into subclades B3 (50.63%, 40/79) and D1 (49.37%, 39/79) through phylogenetic analysis, 31 (77.50%, 31/40) were B3 from 2024, and 34 (87.18%, 34/39) were D1 from 2024. More patients infected with B3 required oxygen supplementation than those infected with D1 (p = 0.042). Therefore, an epidemic of EV-D68 with the co-circulation of B3 and D1 was observed in 2024, with more severe disease caused by B3 than by D1, which underscores the urgent need for surveillance of EV-D68.