Virology · 2010
Rabies virus in insectivorous bats: implications of the diversity of the nucleoprotein and glycoprotein genes for molecular epidemiology.
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Oliveira Rafael de Novaes, de Souza Sibele Pinheiro, Lobo Renata Spinelli Vaz, Castilho Juliana Galera, Macedo Carla Isabel, Carnieli Pedro, Fahl Willian Oliveira, Achkar Samira Maria, Scheffer Karin Corrêa, Kotait Ivanete, Carrieri Maria Luiza, Brandão Paulo Eduardo
Аннотация
Insectivorous bats are the main reservoirs of rabies virus (RABV) in various regions of the world. The aims of this study were to (a) establish genealogies for RABV strains from different species of Brazilian insectivorous bats based on the nucleoprotein (N) and glycoprotein (G) genes, (b) investigate specific RABV lineages associated with certain genera of bats and (c) identify molecular markers that can distinguish between these lineages. The genealogic analysis of N and G from 57 RABV strains revealed seven genus-specific clusters related to the insectivorous bats Myotis, Eptesicus, Nyctinomops, Molossus, Tadarida, Histiotus and Lasiurus. Molecular markers in the amino acid sequences were identified which were specific to the seven clusters. These results, which constitute a novel finding for this pathogen, show that there are at least seven independent epidemiological rabies cycles maintained by seven genera of insectivorous bats in Brazil.