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Respiratory investigation · 2025

Association between nonrestorative sleep status and sleep apnea syndrome: A cross-sectional and longitudinal study using health check-up and health insurance claims data in Japan.

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Takahashi Naomi, Takahashi Yoshimitsu, Murase Kimihiko, Nagata Kazuma, Nakatani Yuka, Hamada Satoshi, Sunadome Hironobu, Togawa Jumpei, Hirai Toyohiro, Chin Kazuo, Nakayama Takeo, Sato Susumu

Аннотация

BACKGROUND: Nonrestorative sleep (NRS) refers to the subjective experience of feeling unrefreshed upon awakening that is not attributed to lack of sleep; NRS is also observed in patients with sleep apnea syndrome (SAS). We investigated the prevalence of NRS among health check-up participants using a single item and further investigated the relationship between NRS status and newly diagnosed SAS using health insurance claims data.

METHODS: We extracted data associated with 93215 participants who underwent health check-ups in 2014 and answered a sleep-related question from a health insurance claims and health check-up database. Patients with SAS were identified via confirmation of the diagnosis and their use of continuous positive airway pressure (CPAP) therapy. Participants without a diagnosis of SAS were followed up for up to 6 years. A Cox proportional hazard model was used to determine whether NRS status was significantly associated with SAS.

RESULTS: The mean age of the participants was 52.3 ± 16.7 years (men: 58.4 %, women: 41.6 %); 32.0 % had NRS status, and 0.8 % had SAS. During the 6-year observation period, among 92050 people, 2.2 % of the patients in the NRS group and 1.3 % of the patients in the non-NRS group were newly diagnosed with SAS. Even after adjusting for other factors, NRS status was a significant risk factor for newly diagnosed SAS (hazard ratio: 1.62, 95 % CI: 1.46-1.81).

CONCLUSIONS: NRS status was a significant risk factor for newly diagnosed SAS. NRS status might be useful as a health check-up screening tool for undiagnosed or subclinical SAS.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты