Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study.
Клиническое исследование III фазыСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Levitt Katz Lorraine E, El Ghormli Laure K, Nadeau Kristen J, Shah Amy, Higgins Janine, Kutney Katherine, Gubitosi-Klug Rose, Burke Brian, Mokhlesi Babak, TODAY Study Group
Аннотация
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.
METHODS: OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean age 23.5 years, diabetes duration 10 years, body mass index 35.3 kg/m2). Glycated hemoglobin, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.
RESULTS: The prevalence of OSA in TODAY was 38.6%. OSA was not associated with glycated hemoglobin, loss of metabolic control, or diabetes-related complications in this cohort.
CONCLUSIONS: Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.
CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY); URL: https://clinicaltrials.gov/study/NCT00081328; Identifier: NCT00081328.
CITATION: Levitt Katz LE, El ghormli LK, Nadeau KJ, et al. Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study. J Clin Sleep Med. 2025;21(11):1925-1933.
METHODS: OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean age 23.5 years, diabetes duration 10 years, body mass index 35.3 kg/m2). Glycated hemoglobin, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.
RESULTS: The prevalence of OSA in TODAY was 38.6%. OSA was not associated with glycated hemoglobin, loss of metabolic control, or diabetes-related complications in this cohort.
CONCLUSIONS: Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.
CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY); URL: https://clinicaltrials.gov/study/NCT00081328; Identifier: NCT00081328.
CITATION: Levitt Katz LE, El ghormli LK, Nadeau KJ, et al. Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study. J Clin Sleep Med. 2025;21(11):1925-1933.