Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.
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Jelenkovic Aline, Yokoyama Yoshie, Sund Reijo, Hur Yoon-Mi, Harris Jennifer R, Brandt Ingunn, Nilsen Thomas Sevenius, Ooki Syuichi, Ullemar Vilhelmina, Almqvist Catarina, Magnusson Patrik K E, Saudino Kimberly J, Stazi Maria A, Fagnani Corrado, Brescianini Sonia, Nelson Tracy L, Whitfield Keith E, Knafo-Noam Ariel, Mankuta David, Abramson Lior, Cutler Tessa L, Hopper John L, Llewellyn Clare H, Fisher Abigail, Corley Robin P, Huibregtse Brooke M, Derom Catherine A, Vlietinck Robert F, Bjerregaard-Andersen Morten, Beck-Nielsen Henning, Sodemann Morten, Krueger Robert F, McGue Matt, Pahlen Shandell, Alexandra Burt S, Klump Kelly L, Dubois Lise, Boivin Michel, Brendgen Mara, Dionne Ginette, Vitaro Frank, Willemsen Gonneke, Bartels Meike, van Beijsterveld Catharina E M, Craig Jeffrey M, Saffery Richard, Rasmussen Finn, Tynelius Per, Heikkilä Kauko, Pietiläinen Kirsi H, Bayasgalan Gombojav, Narandalai Danshiitsoodol, Haworth Claire M A, Plomin Robert, Ji Fuling, Ning Feng, Pang Zengchang, Rebato Esther, Tarnoki Adam D, Tarnoki David L, Kim Jina, Lee Jooyeon, Lee Sooji, Sung Joohon, Loos Ruth J F, Boomsma Dorret I, Sørensen Thorkild I A, Kaprio Jaakko, Silventoinen Karri
Аннотация
AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.
METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses.
RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length.
CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.