Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) · 2011
Prevalence of sensitization to inhaled and food allergens in a group of children with primary renal tubular acidosis.
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Bojórquez-Ochoa Aurora, Morfín-Maciel Blanca María, García-Caballero Rodolfo, Hernández Trinidad, Barbosa Catalina, Zaltzman-Girsevich Samuel
Аннотация
OBJECTIVE: Some reports associate certain illnesses of the urinary system with allergies. Thus, we decided to examine the prevalence of sensitization to allergens in a group of children with primary renal tubular acidosis (RTA).
METHODS: Children with primary RTA who attended the nephrology department at a third level pediatric hospital during a four-month period, were included. With informed parental consent, a questionnaire and skin prick test, total IgE, specific IgE and milk precipitins were performed.
RESULTS: Forty-three children were included, aged 5 months to 9 years (mean, 3.4 ± 1.8 years), and a male/female ratio of 1.7:1. The age of onset of ATR ranged from 2 to 18 months. The most common symptoms at the beginning of disease were: failure to thrive and lack of appetite. Twenty-one parents (48.8%) noticed an association between the introduction of cow´s milk and the beginning of symptoms. Skin tests were positive in 27.9%. Total IgE levels were elevated in 34.9%, ranged from 5.9 to 324 IU/mL. Allergen-specific IgE was positive in 25.6%, mainly for milk, wheat and egg white. The milk precipitins test was positive in 9 patients (21%).
CONCLUSIONS: Although this study demonstrated the existence of allergen sensitization in a group of children with RTA, it is necessary to look for this association in studies with larger sample size and to use tests with higher specificity and sensitivity.
METHODS: Children with primary RTA who attended the nephrology department at a third level pediatric hospital during a four-month period, were included. With informed parental consent, a questionnaire and skin prick test, total IgE, specific IgE and milk precipitins were performed.
RESULTS: Forty-three children were included, aged 5 months to 9 years (mean, 3.4 ± 1.8 years), and a male/female ratio of 1.7:1. The age of onset of ATR ranged from 2 to 18 months. The most common symptoms at the beginning of disease were: failure to thrive and lack of appetite. Twenty-one parents (48.8%) noticed an association between the introduction of cow´s milk and the beginning of symptoms. Skin tests were positive in 27.9%. Total IgE levels were elevated in 34.9%, ranged from 5.9 to 324 IU/mL. Allergen-specific IgE was positive in 25.6%, mainly for milk, wheat and egg white. The milk precipitins test was positive in 9 patients (21%).
CONCLUSIONS: Although this study demonstrated the existence of allergen sensitization in a group of children with RTA, it is necessary to look for this association in studies with larger sample size and to use tests with higher specificity and sensitivity.