Nature communications · 2020

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.

СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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Burn Edward, You Seng Chan, Sena Anthony G, Kostka Kristin, Abedtash Hamed, Abrahão Maria Tereza F, Alberga Amanda, Alghoul Heba, Alser Osaid, Alshammari Thamir M, Aragon Maria, Areia Carlos, Banda Juan M, Cho Jaehyeong, Culhane Aedin C, Davydov Alexander, DeFalco Frank J, Duarte-Salles Talita, DuVall Scott, Falconer Thomas, Fernandez-Bertolin Sergio, Gao Weihua, Golozar Asieh, Hardin Jill, Hripcsak George, Huser Vojtech, Jeon Hokyun, Jing Yonghua, Jung Chi Young, Kaas-Hansen Benjamin Skov, Kaduk Denys, Kent Seamus, Kim Yeesuk, Kolovos Spyros, Lane Jennifer C E, Lee Hyejin, Lynch Kristine E, Makadia Rupa, Matheny Michael E, Mehta Paras P, Morales Daniel R, Natarajan Karthik, Nyberg Fredrik, Ostropolets Anna, Park Rae Woong, Park Jimyung, Posada Jose D, Prats-Uribe Albert, Rao Gowtham, Reich Christian, Rho Yeunsook, Rijnbeek Peter, Schilling Lisa M, Schuemie Martijn, Shah Nigam H, Shoaibi Azza, Song Seokyoung, Spotnitz Matthew, Suchard Marc A, Swerdel Joel N, Vizcaya David, Volpe Salvatore, Wen Haini, Williams Andrew E, Yimer Belay B, Zhang Lin, Zhuk Oleg, Prieto-Alhambra Daniel, Ryan Patrick

Аннотация

Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.

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