[Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps].

OBJECTIVE

To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.

METHOD: Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.

RESULT: Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.

CONCLUSION

The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.