Rivista di psichiatria · 2014
[Treatment-resistant depression: state of the art. Part I. Nosography and clinic].
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Luchini Federica, Cosentino Luca, Pensabene Laura, Mauri Mauro, Lattanzi Lorenzo
Аннотация
AIMS: This work would give an overall vision of the actual knowledge about nosography and clinic of treatment-resistant depression.
METHOD: A PubMed, PsychInfo, Google Scolar search was done using the key words "resistant depression", "STAR*D", "bipolar depression", "staging". Have been selected exclusively works in English, French and Italian languages.
RESULTS: Treatment-resistant depression is one of the most important problem in public health. Nevertheless a general consensus about its definition and staging does not exist at now. Principal risk factors and associated comorbidities are well known including the association with bipolar spectrum; anyway the disease particularly common among depressed outpatients is still very disabling, responsible of an often chronic course, with numerous relapses and high risk of suicide.
DISCUSSION AND CONCLUSION: The future investigations, once improved procedures for differential diagnosis and subtyping of clinical depression, should be directed to the search of a shared definition of treatment resistance and the development of specific therapeutic protocols.
METHOD: A PubMed, PsychInfo, Google Scolar search was done using the key words "resistant depression", "STAR*D", "bipolar depression", "staging". Have been selected exclusively works in English, French and Italian languages.
RESULTS: Treatment-resistant depression is one of the most important problem in public health. Nevertheless a general consensus about its definition and staging does not exist at now. Principal risk factors and associated comorbidities are well known including the association with bipolar spectrum; anyway the disease particularly common among depressed outpatients is still very disabling, responsible of an often chronic course, with numerous relapses and high risk of suicide.
DISCUSSION AND CONCLUSION: The future investigations, once improved procedures for differential diagnosis and subtyping of clinical depression, should be directed to the search of a shared definition of treatment resistance and the development of specific therapeutic protocols.
Предметные рубрики MeSH
Antidepressive AgentsAnxiety DisordersBiotransformationBipolar DisorderComorbidityDepressive Disorder, Treatment-ResistantDiagnosis, DifferentialDrug SubstitutionElectroconvulsive TherapyEndocrine System DiseasesGenetic Predisposition to DiseaseHumansModels, PsychologicalPanic DisorderPsychotherapyRecurrenceRisk FactorsSeverity of Illness IndexTreatment FailureSuicide Prevention