Journal of natural medicines · 2019
Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system.
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Akiyama Hiroshi, Nose Mitsuhiko, Takiguchi Hajime, Sugiyama Keiichi, Tsutsui Riho, Hisaka Shinsuke, Fuchino Hiroyuki, Inui Takayuki, Kawano Noriaki, Taguchi Takaaki, Kudo Tadashi, Kawahara Nobuo, Yoshimatsu Kayo
Аннотация
As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.