Biological psychiatry · 2023
Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.
МетаанализСтатьяОбзорПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Alex Ann M, Buss Claudia, Davis Elysia Poggi, Campos Gustavo de Los, Donald Kirsten A, Fair Damien A, Gaab Nadine, Gao Wei, Gilmore John H, Girault Jessica B, Grewen Karen, Groenewold Nynke A, Hankin Benjamin L, Ipser Jonathan, Kapoor Shreya, Kim Pilyoung, Lin Weili, Luo Shan, Norton Elizabeth S, O'Connor Thomas G, Piven Joseph, Qiu Anqi, Rasmussen Jerod M, Skeide Michael A, Stein Dan J, Styner Martin A, Thompson Paul M, Wakschlag Laurie, Knickmeyer Rebecca, ENIGMA ORIGINs group
Аннотация
Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain development in infancy and early childhood (from birth to age 6 years). This is an important knowledge gap because developmental changes in the brain during the prenatal and early postnatal period are regulated by dynamic gene expression patterns that likely play an important role in establishing an individual's risk for later psychiatric illness and neurodevelopmental disabilities. In this review, we summarize findings from imaging genetics studies spanning from early infancy to early childhood, with a focus on studies examining genetic risk for neuropsychiatric disorders. We also introduce the Organization for Imaging Genomics in Infancy (ORIGINs), a working group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium, which was established to facilitate large-scale imaging genetics studies in infancy and early childhood.