Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy scheme.

OBJECTIVE

Aim: To improve the early diagnosis, course, prediction of the development of Acute Respiratory pathology in children, taking into account the state of antioxidant system (AOS).

PATIENTS AND

METHODS

Materials and

Methods

The research group included school-age children (10-14 years old) with Acute Respiratory pathologe (n=111) and a control group (n=25).diseases in comparation.

RESULTS

Results

The highest positive correlation between ferritin and TNF- α (r=0,41, p=0,001); Cortisol with Glutathione peroxidase (r=0,35, p=0,006) were observed. Ascorbic acid presented positive interactions on the values of Il-6 and Il-2 (r=0,27, 0,26, respectively). The value of vitamin D is represented in positive interactions with γ-IFN (r=0,30), leptin (r=0,38) and Cu (r=0,32). The negative relationship of Zn with Il-6 was transformed for supporting immune barriers and protein metabolism.

CONCLUSION

Conclusions

The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (р3<0,01; р4<0,01; р5<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.