PRAYAS: individual patient data meta-analysis database for Pooled Research and Analysis for Yielding Anemia-free Solutions in India.
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Pandey Anuj Kumar, Sinha Anju Pradhan, Rawat Ramu, Chowdhury Ranadip, Goudar Shivaprasad S, Nagpal Jitender, Desai Shrey, Laxmaiah Avula, Basany Kalpana, Joshi Sadhana, Yajnik Chittaranjan, Mukherjee Aparna, Dwarkanath Pratibha, Bansal Priyanka Gupta, Jacob Molly, Bhatnagar Shinjini, Shah Komal, Mukherjee Debarati, Shukla Amlin, Pullakhandam Raghu, Dhurde Varsha, Apte Aditi, Singh Rajeev, Gupta Aakriti, Priyanka Yamini, Dhingra Usha, Upadhyay Ravi Prakash, Neogi Sutapa Bandyopadhyay, Somannavar Manjunath S, Mandal Anirban, Desai Gayatri, Sengupta Shantanu, Dandge Shailendra, Wagh Girija, Deshmukh Urmila, Kumar Gunjan, Kurpad Anura V, Toteja G S, John Nikhitha Mariya, Sopory Shailaja, Saha Somen, Babu Giridhar R, Suryavanshi Anandika, Palika Ravindranadh, Patel Archana, Nimkar Radhika, Dwivedi Gaurav Raj, Kapil Umesh, Raja Dilip, Dutta Arup, Taneja Sunita, Gautam Diksha, Kavi Avinash, Rawat Swapnil, Dave Kapilkumar, Raman Rajiva, Haggerty Catherine L, Lalwani Sanjay, Phadke Prachi, Turuk Alka, Thomas Tinku, Bhatia Neena, Beck Manisha Madai, Kaur Lovejeet, Shukla Aakansha, Deepa R, Locks Lindsey M, Agarwal Dhiraj Motilal, Mamidi Raja Sriswan, Sachdev Harshpal Singh, Talukdar Rounik, Das Sayan, Bhandari Nita, Singh Ranjana, Yogeshkumar S, Yadav Ramasheesh, Reddy P S, Gupte Sanjay, Ladkat S Rasika, Gonmei Zaozianlungliu, Rathore Swati, Sharma Dharmendra, Pandya Apurvakumar, Ana Yamuna, Hibberd Patricia, Lubree Himangi, Dudekula Anwar Basha, Lal Priti Rishi, Khan Pearlin Amaan, Verma Aruna, Charantimath Umesh S, Meshram Indrapal I, Randhir Karuna, Deshmukh Onkar, Roy Ashok Kumar, John Obed, Saldanha Nolita Dolcy, Bavdekar Ashish, Kumar Raj, Prakash Shyam, Fawzi Wafaie W, Sazawal Sunil
Аннотация
PARTICIPANTS: Children (0-18 years), pregnant women, and NPNL women in India.
FINDINGS TO DATE: The database currently includes 88 datasets (1994-2023), with 319,721 participants for prevalence analysis-children (19,762), NPNL women (17,883), and pregnant women (282,076). Intervention studies comprise 59,292 participants-children (13,435), NPNL women (11,594), and pregnant women (34,263). Over half the datasets (55.7%, 49/88) are randomized controlled trials, while 35.2% (31/88) are observational. Geographically, 43.2% (38/88) are from northern India, 22.7% (20/88) from the west, and 18.2% (16/88) from the south. Most studies (67%, 59/88) are community-based. Median ages were 26 years (IQR 23-32) for NPNL and 23 years (IQR 21-25) for pregnant women, while children's data covered 6 months to 18 years. Mean gestational age at enrollment in pregnancy was 10.24 weeks (SD 17.65). Of the total sample, 10.8% had complete blood count data, 9% ferritin, and 4.5% vitamin B12.Among interventions, pregnant women received intravenous iron sucrose, ferric carboxymaltose, iron isomaltoside, combined IV iron with vitamin B12/folic acid/niacinamide, integrated packages, and low-dose calcium supplementation. NPNL women were often part of trials comparing 60 mg daily ferrous sulfate with 120 mg on alternate days. Children's interventions mainly included ferrous sulfate, food supplementation, and select Ayush-based approaches.
FUTURE PLANS: PRAYAS will generate robust, policy-relevant evidence to refine anemia prevention and treatment strategies. Findings will directly inform the Anemia Mukt Bharat program, supporting targeted, evidence-driven interventions to reduce anemia and associated health burdens across children, women, and pregnant populations in India.
CLINICAL TRIAL REGISTRATION: OSF-https://doi.org/10.17605/OSF.IO/6YRXF.