Medical physics · 2026
Development and dosimetric evaluation of a freely deformable 6Li-based neutron shield for boron neutron capture therapy.
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Hu Naonori, Kakino Ryo, Sasaki Akinori, Nojiri Mai, Akita Kazuhiko, Yoshikawa Syuushi, Kohigashi Yasushi, Yoshino Yuki, Takeno Satoshi, Aihara Teruhito, Takata Takushi, Tanaka Hiroki, Nihei Keiji, Ono Koji
Аннотация
BACKGROUND: Boron neutron capture therapy (BNCT) enables selective tumor irradiation by exploiting the high-linear energy transfer particles generated from neutron interactions with 10B atoms. BNCT has been approved as an insurance-covered medical treatment for recurrent head and neck cancer in Japan. Unlike photon radiotherapy, neutrons that come out of the collimator have an angular distribution. Therefore, it is necessary to keep the distance between the collimator and the patient as short as possible. However, for head and neck cancer treatments, patient anatomy often limits proximity to the collimator, creating an unwanted air gap. This ultimately increases the neutron exposure to surrounding healthy tissue.
PURPOSE: To develop a freely deformable LiF-polyethylene neutron shield and assess its impact on neutron/gamma attenuation and clinical organ at-risk sparing in head and neck BNCT.
METHODS: A freely deformable neutron shielding device was constructed using polyethylene beads loaded with lithium fluoride encapsulated in a vacuum-sealed cushion. Neutron and gamma-ray attenuation were measured in a water phantom under clinical conditions using an accelerator-based BNCT system (NeuCure®, Kansai BNCT Medical Center). Measurements were compared with a solid LiF-polyethylene block and validated through Monte Carlo-based simulations in a commercial treatment planning system. Three representative head and neck cases were further simulated to assess clinical dosimetric effects.
RESULTS: The deformable shielding device reduced the thermal neutron flux by approximately 50%, compared with 60% for the solid LiF-polyethylene block. Simulated head and neck treatments demonstrated significant OAR dose reductions (up to 46.6% in pharyngeal mucosa D50%) without compromising tumor dose coverage (D80% ≥ 20 Gy-eq). Treatment delivery times were minimally affected (< 2 min difference) across all plans. A 5 mm positional perturbation analysis showed ≤ 0.5 Gy-eq variation in GTV Dmin and pharyngeal mucosa D50 and Dmax.
CONCLUSIONS: The freely deformable LiF-based neutron shielding device effectively attenuated stray neutron dose while maintaining target coverage in BNCT. Its adaptability and reusability make it a practical adjunct for patient-specific dose optimization in clinical BNCT applications.
PURPOSE: To develop a freely deformable LiF-polyethylene neutron shield and assess its impact on neutron/gamma attenuation and clinical organ at-risk sparing in head and neck BNCT.
METHODS: A freely deformable neutron shielding device was constructed using polyethylene beads loaded with lithium fluoride encapsulated in a vacuum-sealed cushion. Neutron and gamma-ray attenuation were measured in a water phantom under clinical conditions using an accelerator-based BNCT system (NeuCure®, Kansai BNCT Medical Center). Measurements were compared with a solid LiF-polyethylene block and validated through Monte Carlo-based simulations in a commercial treatment planning system. Three representative head and neck cases were further simulated to assess clinical dosimetric effects.
RESULTS: The deformable shielding device reduced the thermal neutron flux by approximately 50%, compared with 60% for the solid LiF-polyethylene block. Simulated head and neck treatments demonstrated significant OAR dose reductions (up to 46.6% in pharyngeal mucosa D50%) without compromising tumor dose coverage (D80% ≥ 20 Gy-eq). Treatment delivery times were minimally affected (< 2 min difference) across all plans. A 5 mm positional perturbation analysis showed ≤ 0.5 Gy-eq variation in GTV Dmin and pharyngeal mucosa D50 and Dmax.
CONCLUSIONS: The freely deformable LiF-based neutron shielding device effectively attenuated stray neutron dose while maintaining target coverage in BNCT. Its adaptability and reusability make it a practical adjunct for patient-specific dose optimization in clinical BNCT applications.