Journal of neuroengineering and rehabilitation · 2026
Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lu Jiewei, Cheng Yuanyuan, Zhang Xinyuan, Zhu Zhizhong, Yu Yang, Wang Yue, Wu Jialing, Han Jianda, Yu Ningbo
Аннотация
BACKGROUND: Brain synergy and redundancy are emerging as pivotal aspects to understand neural functions, providing insights into high-order information that traditional functional connectivity (FC) methods cannot access. Despite their significance, these aspects have not been investigated in Parkinson's disease (PD). This paper advances the understanding of synergy and redundancy by integrating them with dynamic analysis, which is essential in the investigation of PD.
METHODS: Dynamic brain synergy and redundancy were developed and quantified by the constructed dynamic information decomposition framework, and was applied to walking-state functional near-infrared spectroscopy (fNIRS) signals of 63 PD patients undergoing dopaminergic treatment and 36 healthy controls.
RESULTS: Dynamic brain synergy was restored to normal levels following dopaminergic treatment. Dynamic FC could not access high-order neural information and had insignificant variations in dopaminergic modulation among PD patients, and dynamic brain redundancy also exhibited insignificant treatment-induced variations.
CONCLUSION: Dynamic brain synergy offers an advancing perspective on neural dynamics and promises to uncover high-order functional biomarkers for PD early diagnosis and individualized treatment.
TRIAL REGISTRATION: This study has been registered in Chinese Clinical Trial Registry (ChiCTR1900022655).
METHODS: Dynamic brain synergy and redundancy were developed and quantified by the constructed dynamic information decomposition framework, and was applied to walking-state functional near-infrared spectroscopy (fNIRS) signals of 63 PD patients undergoing dopaminergic treatment and 36 healthy controls.
RESULTS: Dynamic brain synergy was restored to normal levels following dopaminergic treatment. Dynamic FC could not access high-order neural information and had insignificant variations in dopaminergic modulation among PD patients, and dynamic brain redundancy also exhibited insignificant treatment-induced variations.
CONCLUSION: Dynamic brain synergy offers an advancing perspective on neural dynamics and promises to uncover high-order functional biomarkers for PD early diagnosis and individualized treatment.
TRIAL REGISTRATION: This study has been registered in Chinese Clinical Trial Registry (ChiCTR1900022655).