A Near-Infrared Chemiluminescent Probe for Visualizing Norepinephrine in Parkinson's Disease.

Norepinephrine (NE), a key neurotransmitter, plays a crucial role in Parkinson's disease (PD). However, precise tracking NE dynamics during PD pathology remains a significant challenge. Herein, we develop a novel near-infrared chemiluminescent probe (CL-NE) that can visualize the dynamic changes of NE levels in brains experiencing PD. Benefiting from its excellent sensitivity and selectivity, the CL-NE probe is applied to monitor NE dynamics in neuronal cells. Notably, CL-NE successfully observed aberrantly expressed NE in MPTP-induced Parkinson's mouse brains. Overall, our study provides a powerful tool for in vivo NE monitoring, offering valuable insights to improve the pathogenesis, diagnosis, and therapy of PD.