Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015
Non-allergic asthma as a CFTR-related disorder.
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Schulz Angela, Tümmler Burkhard
Аннотация
BACKGROUND: CFTR dysfunction can be involved in CBAVD, pancreatitis or bronchiectasis.
METHODS: Subjects with cystic fibrosis-like disease, equivocal sweat chloride concentrations and no or one disease-causing CFTR mutation were investigated by intestinal current and/or nasal potential difference measurements.
RESULTS: A subgroup of female patients who had been diagnosed to suffer from non-allergic asthma showed intermediary chloride concentrations in sweat test, normal chloride secretory responses in the intestine and an abnormal nasal potential difference with Sermet scores in the cystic fibrosis range.
CONCLUSION: Non-allergic asthma is a clinical entity that may be associated with CFTR dysfunction of the respiratory epithelium.
METHODS: Subjects with cystic fibrosis-like disease, equivocal sweat chloride concentrations and no or one disease-causing CFTR mutation were investigated by intestinal current and/or nasal potential difference measurements.
RESULTS: A subgroup of female patients who had been diagnosed to suffer from non-allergic asthma showed intermediary chloride concentrations in sweat test, normal chloride secretory responses in the intestine and an abnormal nasal potential difference with Sermet scores in the cystic fibrosis range.
CONCLUSION: Non-allergic asthma is a clinical entity that may be associated with CFTR dysfunction of the respiratory epithelium.