Nature communications · 2025
Ventral hippocampus neurons encode meal-related memory.
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Décarie-Spain Léa, Gu Cindy, Tierno Lauer Logan, Subramanian Keshav S, Chehimi Samar N, Kao Alicia E, Gao Serena X, Deng Iris, Bashaw Alexander G, Klug Molly E, Rea Jessica J, Waldow Alice I, Galbokke Ashyah Hewage, Moody Olivia, Donohue Kristen N, Yang Mingxin, de Lartigue Guillaume, Myers Kevin P, Crist Richard C, Reiner Benjamin C, Hayes Matthew R, Kanoski Scott E
Аннотация
The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates between eating bouts during meal consumption and this response is predictive of performance in a foraging-related memory test for the spatial location of a previously consumed meal. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs meal location memory without influencing food motivation or spatial memory for escape location. These HPCv meal-responsive neurons project to the lateral hypothalamic area (LHA) and are enriched in serotonin 2a receptors (5HT2aR). Either chemogenetic silencing of HPCv-to-LHA projections or intra-HPCv 5HT2aR antagonist yielded meal location memory deficits, as well as increased caloric intake driven by shorter temporal intervals between meals. Collective results identify a population of HPCv neurons in male rats that dynamically respond during eating to encode meal-related memories.