CNS & neurological disorders drug targets · 2014
Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.
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de Mello Schier Alexandre R, de Oliveira Ribeiro Natalia P, Coutinho Danielle S, Machado Sergio, Arias-Carrión Oscar, Crippa Jose A, Zuardi Antonio W, Nardi Antonio E, Silva Adriana C
Аннотация
Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.