Current medical research and opinion · 2014
Prevalence and risk of developing comorbid conditions in patients with chronic constipation.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mody Reema, Guérin Annie, Fok Beverly, Lasch Karen L, Zhou Zhou, Wu Eric Q, Zhou Wen, Talley Nicholas J
Аннотация
OBJECTIVE: To estimate the prevalence of gastrointestinal (GI) and non-GI comorbidities and the risk of incident comorbidities among patients with and without chronic constipation (CC).
RESEARCH DESIGN AND METHODS: Adults with CC were identified from a large retrospective US claims database. Each CC patient was matched 1:3 to CC-free patients by birth year, sex, and region of residence.
MAIN OUTCOME MEASURES: Prevalence of GI and non-GI comorbidities was measured over a 1-year period. Relative risk of new comorbidities was also estimated among patients who were free of the studied comorbidity prior to the index date.
RESULTS: Mean age was 61.9 years; 33.3% of patients were male. The 1-year prevalence of GI comorbidities was significantly higher in CC (N = 28,854) vs. CC-free (N = 86,562) patients (all p < 0.05). The risk of developing new GI conditions was also significantly higher in CC patients for all studied conditions except ulcerative colitis: megacolon (hazard ratio [95% confidence interval] HR [CI] = 11.96 [8.16-17.53]), intestinal impaction (10.56 [9.22-12.10]), volvulus (7.12 [5.42-9.35]), other specified functional intestinal disorders (6.67 [5.57-8.00]), and other unspecified functional disorders of intestine (4.60 [3.61-5.87]). Similarly, 1-year prevalence of non-GI comorbidities was higher in CC patients, as was the risk of developing new conditions: depression and mood disorder (HR [CI] = 1.84 [1.77-1.90]), neurological disorders (1.68 [1.62-1.74]), iron deficiency anemia (1.52 [1.47-1.57]), hypothyroidism (1.40 [1.34-1.46]), and peripheral vascular disorders (1.40 [1.34-1.46]).
LIMITATIONS: An algorithm was used to define CC as there is no specific diagnosis code to identify CC.
CONCLUSIONS: CC patients had significantly higher prevalence and were at increased risk of developing new GI and non-GI comorbidities than age-, gender- and region-matched CC-free patients. Future research is warranted to better understand these associations.
RESEARCH DESIGN AND METHODS: Adults with CC were identified from a large retrospective US claims database. Each CC patient was matched 1:3 to CC-free patients by birth year, sex, and region of residence.
MAIN OUTCOME MEASURES: Prevalence of GI and non-GI comorbidities was measured over a 1-year period. Relative risk of new comorbidities was also estimated among patients who were free of the studied comorbidity prior to the index date.
RESULTS: Mean age was 61.9 years; 33.3% of patients were male. The 1-year prevalence of GI comorbidities was significantly higher in CC (N = 28,854) vs. CC-free (N = 86,562) patients (all p < 0.05). The risk of developing new GI conditions was also significantly higher in CC patients for all studied conditions except ulcerative colitis: megacolon (hazard ratio [95% confidence interval] HR [CI] = 11.96 [8.16-17.53]), intestinal impaction (10.56 [9.22-12.10]), volvulus (7.12 [5.42-9.35]), other specified functional intestinal disorders (6.67 [5.57-8.00]), and other unspecified functional disorders of intestine (4.60 [3.61-5.87]). Similarly, 1-year prevalence of non-GI comorbidities was higher in CC patients, as was the risk of developing new conditions: depression and mood disorder (HR [CI] = 1.84 [1.77-1.90]), neurological disorders (1.68 [1.62-1.74]), iron deficiency anemia (1.52 [1.47-1.57]), hypothyroidism (1.40 [1.34-1.46]), and peripheral vascular disorders (1.40 [1.34-1.46]).
LIMITATIONS: An algorithm was used to define CC as there is no specific diagnosis code to identify CC.
CONCLUSIONS: CC patients had significantly higher prevalence and were at increased risk of developing new GI and non-GI comorbidities than age-, gender- and region-matched CC-free patients. Future research is warranted to better understand these associations.