The Journal of infectious diseases · 2025
Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria.
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Namazzi Ruth, Kazinga Caroline, Lima-Cooper Giselle, Liepmann Claire, Goings Michael J, Bednarski Olivia, Abreu Marco, Schwantes-An Tae-Hwi, Batte Anthony, Opoka Robert O, John Chandy C, Conroy Andrea L
Аннотация
Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.