Current aging science · 2017
Factors of Rapid Cognitive Decline in Late Onset Alzheimer's Disease.
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Koskas Pierre, Henry-Feugeas Marie Cecile, Feugeas Jean-Paul, Ou Phalla, Drunat Olivier
Аннотация
BACKGROUND: Rapid Cognitive Decline (RCD) in Alzheimer's Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD.
OBJECTIVE: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD.
METHODS: Community-dwelling subjects aged >75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered. All patients underwent a standardized clinical dementia investigation. Patients were classified as rapid decliners when they demonstrated a loss of 3 points or greater in MMSE during the first six months.
RESULTS: 130 patients were included (42 males, 88 females, mean ages 82.7±4.58). The average baseline MMSE score was 23.36±3.78. In regression analysis, the Free Recall Scores, categorical fluency scores were the most highly predictive of RCD.
CONCLUSION: These results are important for the design of clinical trials and also, in clinical practice, for both physicians and families in planning long-term care.
OBJECTIVE: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD.
METHODS: Community-dwelling subjects aged >75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered. All patients underwent a standardized clinical dementia investigation. Patients were classified as rapid decliners when they demonstrated a loss of 3 points or greater in MMSE during the first six months.
RESULTS: 130 patients were included (42 males, 88 females, mean ages 82.7±4.58). The average baseline MMSE score was 23.36±3.78. In regression analysis, the Free Recall Scores, categorical fluency scores were the most highly predictive of RCD.
CONCLUSION: These results are important for the design of clinical trials and also, in clinical practice, for both physicians and families in planning long-term care.
Предметные рубрики MeSH
Activities of Daily LivingAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCognitionComorbidityDiscriminant AnalysisDisease ProgressionFemaleHumansIndependent LivingLinear ModelsLogistic ModelsMaleMental RecallMental Status and Dementia TestsNeuropsychological TestsParisPrognosisRisk FactorsTime FactorsVerbal Behavior