Pediatric transplantation · 2026
Functional, Volumetric, and Growth Outcomes After Pediatric Bilateral Lung Transplantation.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bae Seon Yong, Park Samina, Kim Dae Hyeon, Yun Taeyoung, Park Ji Hyeon, Na Bubse, Na Kwon Joong, Lee Hyun Joo, Park Ji Soo, Suh Dong In, Park Jimyung, Park In Kyu, Kang Chang Hyun, Kim Young Tae
Аннотация
OBJECTIVE: Long-term multidimensional evaluations of pediatric lung transplantation are limited. This study assessed the functional recovery, volumetric adaptation, and growth in pediatric recipients by comparing age and graft type.
METHODS: This single-center, retrospective, descriptive study longitudinally reviewed 16 children (age < 18 years) who underwent bilateral deceased-donor lung transplantation. Perioperative characteristics, pulmonary function, computed tomography (CT)-derived lung volume, somatic growth, and survival were analyzed. Overall survival (OS) and chronic lung allograft dysfunction (CLAD)-free survival were estimated using the Kaplan-Meier method, and longitudinal physiological and developmental patterns were assessed descriptively.
RESULTS: In the younger group (≤ 10 years, n = 7) and the older group (> 10 years, n = 9), lobar transplantation was performed in 5 (71.4%) and 3 (33.3%) patients, respectively. CLAD was diagnosed in 1 younger recipient (14.3%) and 2 older recipients (22.2%). OS did not differ significantly between age groups (log-rank p = 0.96), and CLAD-free survival was comparable (log-rank p = 0.73). CT volumetry demonstrated progressive postoperative lung expansion with similar temporal trajectories across age groups and between lobar and whole-lung grafts. Growth patterns demonstrated meaningful postoperative improvement, with many children who exhibited faltering pretransplant growth demonstrating catch-up toward individualized percentile curves.
CONCLUSIONS: Pediatric lung transplantation results in favorable long-term recovery, including functional improvement, durable volumetric adaptation, and partial restoration of growth dynamics. Comparable outcomes between lobar and whole-lung grafts support the use of size-reduced grafts in cases of donor-recipient mismatch.
METHODS: This single-center, retrospective, descriptive study longitudinally reviewed 16 children (age < 18 years) who underwent bilateral deceased-donor lung transplantation. Perioperative characteristics, pulmonary function, computed tomography (CT)-derived lung volume, somatic growth, and survival were analyzed. Overall survival (OS) and chronic lung allograft dysfunction (CLAD)-free survival were estimated using the Kaplan-Meier method, and longitudinal physiological and developmental patterns were assessed descriptively.
RESULTS: In the younger group (≤ 10 years, n = 7) and the older group (> 10 years, n = 9), lobar transplantation was performed in 5 (71.4%) and 3 (33.3%) patients, respectively. CLAD was diagnosed in 1 younger recipient (14.3%) and 2 older recipients (22.2%). OS did not differ significantly between age groups (log-rank p = 0.96), and CLAD-free survival was comparable (log-rank p = 0.73). CT volumetry demonstrated progressive postoperative lung expansion with similar temporal trajectories across age groups and between lobar and whole-lung grafts. Growth patterns demonstrated meaningful postoperative improvement, with many children who exhibited faltering pretransplant growth demonstrating catch-up toward individualized percentile curves.
CONCLUSIONS: Pediatric lung transplantation results in favorable long-term recovery, including functional improvement, durable volumetric adaptation, and partial restoration of growth dynamics. Comparable outcomes between lobar and whole-lung grafts support the use of size-reduced grafts in cases of donor-recipient mismatch.