Journal of neurology, neurosurgery, and psychiatry · 2007
Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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del Mar Matarín María, Pueyo Roser, Poca María Antonia, Falcón Carles, Mataró María, Bargalló Núria, Sahuquillo Juan, Junqué Carme
Аннотация
BACKGROUND: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.
OBJECTIVES: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.
METHODS: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.
RESULTS: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
CONCLUSION: MRS could be a marker of neuronal dysfunction in NPH.
OBJECTIVES: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.
METHODS: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.
RESULTS: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
CONCLUSION: MRS could be a marker of neuronal dysfunction in NPH.