Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Associations between parental history of dementia and plasma markers of inflammation in a multi-ethnic middle-aged community of adults.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Winford Edric D, Huber Benjamin D, Seblova Dominika, Pyne Jeffrey, Avila-Rieger Justina F, Turney Indira C, Mazen Jessica A, Brickman Adam M, Manly Jennifer J
Аннотация
INTRODUCTION: Parental history of dementia is associated with increased dementia risk. We investigated whether having a parent with dementia is associated with increased peripheral inflammation in middle-aged adults.
METHODS: Participants were from the Offspring Study (n = 1204). Parental dementia status was determined by a diagnostic consensus conference. Plasma chemokine and cytokine concentrations were assayed with Luminex technology.
RESULTS: Parental history of dementia was associated with higher levels of eotaxin and lower levels of granulocyte colony-stimulating factor, vascular endothelial growth factor A, and interleukin (IL)-27. IL-18 and epidermal growth factor levels were higher in Black individuals with a parental history of dementia compared to Hispanic individuals with the same history. Women with a parental history of dementia had higher levels of interferon-alpha 2, IL-12p70, soluble CD40 ligand, and IL-18 compared to men with the same history.
DISCUSSION: Parental history of dementia is associated with elevated markers of peripheral inflammation. These associations vary across sex, race, and ethnicity.
METHODS: Participants were from the Offspring Study (n = 1204). Parental dementia status was determined by a diagnostic consensus conference. Plasma chemokine and cytokine concentrations were assayed with Luminex technology.
RESULTS: Parental history of dementia was associated with higher levels of eotaxin and lower levels of granulocyte colony-stimulating factor, vascular endothelial growth factor A, and interleukin (IL)-27. IL-18 and epidermal growth factor levels were higher in Black individuals with a parental history of dementia compared to Hispanic individuals with the same history. Women with a parental history of dementia had higher levels of interferon-alpha 2, IL-12p70, soluble CD40 ligand, and IL-18 compared to men with the same history.
DISCUSSION: Parental history of dementia is associated with elevated markers of peripheral inflammation. These associations vary across sex, race, and ethnicity.