[Prostaglandin and cyclic nucleotide levels in patients with peptic ulcer and chronic gastritis with secretory insufficiency].

A study of prostaglandins (PGE2 and PGF2) and cyclic nucleotides (cAMP, cGMP) in the blood and gastric mucosa biopsies was carried out. In peptic ulcer the level of cyclic nucleotides in the blood and gastric mucosa was on an increase. The level of prostaglandins increased in the blood and decreased in the gastric mucosa. A decrease in the level of prostaglandins and cAMP in the blood and gastric mucosa was noted in patients with chronic atrophic histamine refractory gastritis with a simultaneous rise of the cAMP level. It was shown that stable stimulation of cyclic nucleotides resulting in an increase of gastric acid production, might cause ulcer development and exacerbation of disease. In patients with chronic atrophic gastritis changes of prostaglandins and cyclic nucleotides as compared to those in patients with peptic ulcer, were contrary.