Blepharoptosis and HAART related mitochondrial myopathy.

PURPOSE: To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy.

METHODS

A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years.

RESULTS

Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions.

CONCLUSIONS

This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.