COVID-19 in people with Cystic Fibrosis beyond the pre-omicron era: a prospective study with a specific focus on long COVID.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Colombo Carla, Medino Paola, Cipolli Marco, Lucca Francesca, Cucchetto Giulia, Alghisi Federico, Ciciriello Fabiana, Sepe Angela, Romano Camilla, Taccetti Giovanni, Francalanci Michela, Ambroni Maura, Donati Valentina, Pizzamiglio Giovanna, Spotti Maura, Rotolo Novella, Lucanto Maria Cristina, Cristadoro Simona, Ficili Francesca, Leonetti Giuseppina, Giordano Paola, Bignamini Elisabetta, Rizza Elvira, Pisi Giovanna, Fainardi Valentina, Casciaro Rosaria, Formigoni Clelia, Ros Mirco, Comello Isabella, Poli Piercarlo, Vitullo Pamela, Messore Barbara, Riberi Luca, Palladino Nicola, Rosazza Chiara, Alicandro Gianfranco, Blasi Francesco
Аннотация
METHODS: This prospective, multicentre study enrolled individuals with confirmed SARS-CoV-2 infection between July 2021 and October 2022. Data collected included clinical features prior to infection, symptoms during the acute phase, hospitalization and symptom persistence after 1 and 6 months. Long COVID was defined according to CDC criteria as persistence of at least one COVID-related symptom for one or more months after diagnosis. The mean variation of FEV1 recorded 6 months after acute infection was also evaluated.
RESULTS: A total of 1102 people with CF were recruited (median age: 18 years, 520 younger than 18). The infection was symptomatic in 90.1 % of cases. During the acute phase, 8 subjects required oxygen support; 31 were hospitalized, one patient required intensive care. Complications included one thromboembolic event and two episodes of myocarditis, but no patient died. Mean variation of FEV1 after 6 months from the infection was +1.8 % (95 % CI: 1.0-2.7). Long COVID was documented in 64 subjects (5.8 %, 95 % CI: 4.5-7.4) with a variety of symptoms which were still present in 12 cases 6 months after infection (1.1 %, 95 % CI: 0.6-1.9).
CONCLUSIONS: In the omicron phase of the pandemic, COVID-19 was relatively mild and did not negatively impact pulmonary function after 6 months. Long COVID was observed at all ages, but extrapulmonary symptoms were more frequent and persistent in adults.