Indian journal of dermatology, venereology and leprology · 2009
Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
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Mehta Timir Y, Prajapati Laxman M, Mittal Bharti, Joshi Chaitanya G, Sheth Jayesh J, Patel Dinesh B, Dave Dinkar M, Goyal Ramesh K
Аннотация
BACKGROUND: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.
AIM: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
METHODS: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.
RESULTS: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.
CONCLUSION: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
AIM: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
METHODS: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.
RESULTS: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.
CONCLUSION: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.