Archives of Iranian medicine · 2024
Causes of Colectomy in Patients with Ulcerative Colitis: Findings from an Iranian National Registry.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Momayez Sanat Zahra, Vahedi Homayoon, Malekzadeh Reza, Kasaeian Amir, Mohammadi Ganjaroudi Negar, Sima Alireza, Mansour Ghanaei Fariborz, Ghadir Mohammadreza, Tirgar Fakheri Hafez, Nasseri Moghaddam Siavosh, Alatab Sudabeh, Sadeghi Anahita, Anushiravani Amir, Maleki Iradj, Yazdanbod Abbas, Vossoughinia Hassan, Seyyedmajidi Mohammadreza, Naghshbandi Sayed Jalaleddin, Baniasadi Nadieh, Parhizkar Baran, Matinkhah Saied, Gheibi Shahsanam, Hosseini Hemmat Abadi Roya-Sadat, Valizadeh Toosi Seyedmohamad
Аннотация
BACKGROUND: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients' health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study.
METHODS: We analyzed data from the Iranian Registry of Crohn's and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors.
RESULTS: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors.
CONCLUSION: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.
METHODS: We analyzed data from the Iranian Registry of Crohn's and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors.
RESULTS: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors.
CONCLUSION: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.