Annals of epidemiology · 2016
Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort.
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Akinyemiju Tomi F, Tehranifar Parisa, Flom Julie D, Liao Yuyan, Wei Ying, Terry Mary Beth
Аннотация
PURPOSE: Rapid infant and childhood growth has been associated with chronic disease later in life, including breast cancer. Early life socioeconomic status (SES) influences childhood growth, but few studies have prospective measures from birth to consider the effects of early life growth and SES on breast cancer risk.
METHODS: We used prospectively measured early life SES and growth (percentile weight change in height and weight between each pair of consecutive time points at birth, 4 months, 1 and 7 years). We performed linear regression models to obtain standardized estimates of the association between 1 standard deviation increase in early life SES and growth and adult mammographic density (MD), a strong risk factor for breast cancer, in a diverse birth cohort (n = 151; 37% white, 38% black, 25% Puerto Rican; average age at mammogram = 42.4).
RESULTS: In models adjusted for race/ethnicity, prenatal factors, birthweight, infant and childhood growth, and adult body mass index, percentile weight change from 1 year to 7 years was inversely associated with percent MD (standardized coefficient (Stdβ) = -0.28, 95% CI: -0.55 to -0.01), and higher early life SES was positively associated with percent MD (Stdβ = 0.24, 95% CI: 0.04-0.43). Similar associations were observed for dense area, but those estimates were not statistically significant.
CONCLUSIONS: These results suggest opposite and independent effects of early life SES and growth on MD.
METHODS: We used prospectively measured early life SES and growth (percentile weight change in height and weight between each pair of consecutive time points at birth, 4 months, 1 and 7 years). We performed linear regression models to obtain standardized estimates of the association between 1 standard deviation increase in early life SES and growth and adult mammographic density (MD), a strong risk factor for breast cancer, in a diverse birth cohort (n = 151; 37% white, 38% black, 25% Puerto Rican; average age at mammogram = 42.4).
RESULTS: In models adjusted for race/ethnicity, prenatal factors, birthweight, infant and childhood growth, and adult body mass index, percentile weight change from 1 year to 7 years was inversely associated with percent MD (standardized coefficient (Stdβ) = -0.28, 95% CI: -0.55 to -0.01), and higher early life SES was positively associated with percent MD (Stdβ = 0.24, 95% CI: 0.04-0.43). Similar associations were observed for dense area, but those estimates were not statistically significant.
CONCLUSIONS: These results suggest opposite and independent effects of early life SES and growth on MD.
Предметные рубрики MeSH
AdolescentAdultBlack or African AmericanBirth WeightBody HeightBody Mass IndexBreast DensityBreast NeoplasmsChildChild DevelopmentChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornLinear ModelsMammographyMultivariate AnalysisPredictive Value of TestsProspective StudiesSocioeconomic FactorsUnited StatesUrban PopulationWhite People