Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study.
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Rashidi-Ranjbar Neda, Churchill Nathan W, Black Sandra E, Kumar Sanjeev, Tartaglia Maria C, Freedman Morris, Lang Anthony, Steeves Thomas D L, Swartz Richard H, Saposnik Gustavo, Sahlas Dametrios, McLaughlin Paula, Symons Sean, Strother Stephen, Pollock Bruce G, Rajji Tarek K, Ozzoude Miracle, Tan Brian, Arnott Stephen R, Bartha Robert, Borrie Michael, Masellis Mario, Pasternak Stephen H, Frank Andrew, Seitz Dallas, Ismail Zahinoor, Tang-Wai David F, Casaubon Leanne K, Mandzia Jennifer, Jog Mandar, Scott Christopher J M, Dowlatshahi Dar, Hassan Ayman, Grimes David, Marras Connie, Zamyadi Mojdeh, Munoz David G, Ramirez Joel, Berezuk Courtney, Holmes Melissa, Fischer Corinne E, Schweizer Tom A
Аннотация
METHODS: The study included individuals with MCI due to AD, (n = 74), CVD (n = 143), and PD (n = 137) at baseline, and at 2-years follow-up (MCI due to AD, n = 37, CVD n = 103, and PD n = 84). We assessed the severity of NPS using the Neuropsychiatric Inventory Questionnaire. For brain structure we included cortical thickness and subcortical volume of predefined regions of interest associated with corticolimbic and frontal-executive circuits.
RESULTS: Cross-sectional analysis revealed significant negative correlations between appetite with both circuits in the MCI and CVD groups, while apathy was associated with these circuits in both the MCI and PD groups. Longitudinally, changes in apathy scores in the MCI group were negatively linked to the changes of the frontal-executive circuit. In the CVD group, changes in agitation and nighttime behavior were negatively associated with the corticolimbic and frontal-executive circuits, respectively. In the PD group, changes in disinhibition and apathy were positively associated with the corticolimbic and frontal-executive circuits, respectively.
CONCLUSIONS: The observed correlations suggest that underlying pathological changes in the brain may contribute to alterations in neural activity associated with MBI. Notably, the difference between cross-sectional and longitudinal results indicates the necessity of conducting longitudinal studies for reproducible findings and drawing robust inferences.