Bioscience, biotechnology, and biochemistry · 2024
Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.
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So Masatomo, Ono Misaki, Oogai Shigeki, Kondo Minako, Yamazaki Kaede, Nachtegael Charlotte, Hamajima Hiroshi, Mutoh Risa, Kato Masaki, Kawate Hisaya, Oki Tomoyuki, Kawata Yasushi, Kumamoto Shiho, Tokui Noritaka, Takei Toshiki, Shimizu Kuniyoshi, Inoue Akio, Yamamoto Naoki, Unoki Motoko, Tanabe Kenichi, Nakashima Kinichi, Sasaki Hiroyuki, Hojo Hironobu, Nagata Yasuo, Suetake Isao
Аннотация
Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.