Journal of psychosomatic research · 2026
Cross-sectional survey: Characteristics and associated factors of cancer-related fatigue in patients after glioma surgery.
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Han Jianfei, Wei Jun, Li Na, Jing Yanan, Zhang Haizhen, Li Hongchao
Аннотация
OBJECTIVE: cancer-related fatigue (CRF) is a common symptom in patients following glioma surgery. This cross-sectional study aimed to determine the prevalence and severity of CRF in this population and to identify its independent associated factors. A pre-specified objective was to compare CRF characteristics between patients with high-grade gliomas (HGG) and low-grade gliomas (LGG).
METHODS: Data were collected from 124 postoperative glioma patients using a battery of standardized scales, including the Piper Fatigue Scale (PFS), Memorial Symptom Assessment Scale-Short Form (MSAS-SF), Hospital Anxiety and Depression Scale (HADS), Perceived Social Support Scale (PSSS), and General Self-Efficacy Scale (GSES). CRF was assessed using the 22-item PFS, with a score ≥ 4 defining moderate-to-severe fatigue. Univariate analyses, multivariate logistic regression, and multiple linear regression analyses were employed to identify influencing factors for both the dichotomous and continuous CRF outcomes. A pre-specified subgroup analysis was conducted comparing patients with HGGs (WHO III-IV) and LGGs (WHO I-II). with additional exploratory analysis by IDH mutation status.
RESULTS: HGG patients had a significantly higher incidence of moderate/severe CRF (79.69 % vs. 65.00 %). Multivariate analysis identified independent risk factors: lower education (OR = 2.44, 95 % CI: 1.05-5.68), high tumor grade (OR = 3.69, 95 % CI: 1.26-10.79), preoperative epilepsy (OR = 6.99, 95 % CI: 1.36-35.91), higher symptom distress (OR = 1.27, 95 % CI: 1.12-1.44), lower social support (OR = 0.90, 95 % CI: 0.84-0.97), depression (OR = 1.19, 95 % CI: 1.03-1.38), and lower self-efficacy (OR = 0.87, 95 % CI: 0.78-0.96).
CONCLUSION: CRF is highly prevalent and severe among postoperative glioma patients, especially in those with HGG. The management of CRF should be a priority in clinical practice, emphasizing early screening and multifaceted interventions targeting psychological state and social support, particularly for high-risk populations such as HGG patients, those with lower socioeconomic status, and tumors in critical functional lobes.
METHODS: Data were collected from 124 postoperative glioma patients using a battery of standardized scales, including the Piper Fatigue Scale (PFS), Memorial Symptom Assessment Scale-Short Form (MSAS-SF), Hospital Anxiety and Depression Scale (HADS), Perceived Social Support Scale (PSSS), and General Self-Efficacy Scale (GSES). CRF was assessed using the 22-item PFS, with a score ≥ 4 defining moderate-to-severe fatigue. Univariate analyses, multivariate logistic regression, and multiple linear regression analyses were employed to identify influencing factors for both the dichotomous and continuous CRF outcomes. A pre-specified subgroup analysis was conducted comparing patients with HGGs (WHO III-IV) and LGGs (WHO I-II). with additional exploratory analysis by IDH mutation status.
RESULTS: HGG patients had a significantly higher incidence of moderate/severe CRF (79.69 % vs. 65.00 %). Multivariate analysis identified independent risk factors: lower education (OR = 2.44, 95 % CI: 1.05-5.68), high tumor grade (OR = 3.69, 95 % CI: 1.26-10.79), preoperative epilepsy (OR = 6.99, 95 % CI: 1.36-35.91), higher symptom distress (OR = 1.27, 95 % CI: 1.12-1.44), lower social support (OR = 0.90, 95 % CI: 0.84-0.97), depression (OR = 1.19, 95 % CI: 1.03-1.38), and lower self-efficacy (OR = 0.87, 95 % CI: 0.78-0.96).
CONCLUSION: CRF is highly prevalent and severe among postoperative glioma patients, especially in those with HGG. The management of CRF should be a priority in clinical practice, emphasizing early screening and multifaceted interventions targeting psychological state and social support, particularly for high-risk populations such as HGG patients, those with lower socioeconomic status, and tumors in critical functional lobes.