Evaluation of melatonin on the precocious puberty: a pilot study.

OBJECTIVE

To evaluate the effect of 6-sulphatoxymelatonin on the sleep quality of girls with precocious puberty.

STUDY

DESIGN

Ninety-nine girls were divided into three groups: GI, precocious puberty; GII, normal prepubescent; GIII, normal puberty. Questionnaires containing demographic and clinical data were applied. Blood was collected for hormonal evaluation for 6-sulphatoxymelatonin. The modified Rush Sleep Diary was used.

RESULTS

The levels of 6-sulphatoxymelatonin were highest in the group without pubertal development (75.23 ± 10.84 ng/ml), second highest in the group with normal puberty (45.66 ± 3.87 ng/ml, p < 0.001) and lowest in the group with true precocious puberty (37.04 ± 5.47 ng/ml). The amount of day sleep was greater in the group without pubertal development compared to other groups.

CONCLUSION

Despite the sleep data, melatonin may be involved in the precocious puberty process.