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DOI 10.1007/s00508-016-0984-y

Медицинская библиотека · Wiener klinische Wochenschrift · 2016

Crizotinib-induced toxicity in an experimental rat model.

Gumusay Ozge, Esendagli-Yilmaz Guldal, Uner Aytug, Cetin Bulent, Buyukberber Suleyman, Benekli Mustafa, Ilhan Mustafa N, Coskun Ugur, Gulbahar Ozlem, Ozet Ahmet

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Аннотация

AIM: The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model.

METHODS

Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively.

RESULTS

Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas.

CONCLUSION

This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.

Для цитирования: Gumusay Ozge, Esendagli-Yilmaz Guldal, Uner Aytug, Cetin Bulent, Buyukberber Suleyman, Benekli Mustafa, Ilhan Mustafa N, Coskun Ugur, Gulbahar Ozlem, Ozet Ahmet. Crizotinib-induced toxicity in an experimental rat model.. Wiener klinische Wochenschrift. 2016. DOI: 10.1007/s00508-016-0984-y.

Предметные рубрики MeSH

Administration, OralAnimalsAntineoplastic AgentsCrizotinibDisease Models, AnimalDose-Response Relationship, DrugMaleOrgan SpecificityPyrazolesPyridinesRatsRats, WistarTreatment OutcomeViscera
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