International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Attaher Oumar, Swihart Bruce, Dang Lauren, Santara Gaoussou, Mahamar Almahamoudou, Keita Sekouba, Dembele Adama, Diarra Bacary Soumana, Issiaka Djibrilla, Barry Amadou, Sidibé Youssoufa, Dicko Yahia T, Traore Seydou, Koita Fanta, Ndiaye Ouelematou, Dicko Alassane, Kurtis Jonathan D, Duffy Patrick E, Fried Michal
Аннотация
OBJECTIVES: The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described the protective role of platelets in directly killing Plasmodium parasites, mediated by platelet factor 4 (PF4) binding to Duffy antigen. This study aimed to evaluate the protective role of platelets in young children who are Duffy antigen-negative, such as those in sub-Saharan Africa.
METHODS: A zero-inflated negative binomial model was used to relate platelet count and parasite density data collected in a longitudinal birth cohort. Platelet factors were measured by enzyme-linked immunosorbent assay in samples collected from malaria-infected children who participated in a cross-sectional study.
RESULTS: We described that an increase of 10,000 platelets/μl was associated with a 2.76% reduction in parasite count. Increasing levels of PF4 and CXCL7 levels were also significantly associated with a reduction in parasite count.
CONCLUSIONS: Platelets play a protective role in reducing parasite burden in Duffy-negative children, possibly mediated through activation of the innate immune system.
METHODS: A zero-inflated negative binomial model was used to relate platelet count and parasite density data collected in a longitudinal birth cohort. Platelet factors were measured by enzyme-linked immunosorbent assay in samples collected from malaria-infected children who participated in a cross-sectional study.
RESULTS: We described that an increase of 10,000 platelets/μl was associated with a 2.76% reduction in parasite count. Increasing levels of PF4 and CXCL7 levels were also significantly associated with a reduction in parasite count.
CONCLUSIONS: Platelets play a protective role in reducing parasite burden in Duffy-negative children, possibly mediated through activation of the innate immune system.