Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2013
Evidence of diminished FEV1 and FVC in 6-year-olds followed in the European Cystic Fibrosis Patient Registry, 2007-2009.
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VanDevanter Donald R, Pasta David J
Аннотация
BACKGROUND: Many infants with cystic fibrosis (CF) exhibit airway inflammation, gas trapping, bronchiectasis, and/or reduced flow, but by age 6 years have forced vital capacities (FVC) and expiratory volumes in 1 second (FEV1) within the variability range of the normal population. We sought evidence of diminished FVC and FEV1 in 6-year-olds with CF.
METHODS: GLI 2012 FVC and FEV1 Z-scores for 6-year-olds from the European CF Patient Registry were plotted against theoretical values from the Normal distribution.
RESULTS: Mean FVC and FEV1 Z-scores for 681 patients (322 females) were -0.43 (SD=1.41) and -0.65 (1.40). Z-scores were consistently lower than expected for the normative population by quantile-quantile plot.
CONCLUSIONS: Diminished FEV1, and to a lesser extent FVC, is found in a large majority of this population, consistent with an established body of evidence that loss of lung function begins early in life for most, if not all, children with CF.
METHODS: GLI 2012 FVC and FEV1 Z-scores for 6-year-olds from the European CF Patient Registry were plotted against theoretical values from the Normal distribution.
RESULTS: Mean FVC and FEV1 Z-scores for 681 patients (322 females) were -0.43 (SD=1.41) and -0.65 (1.40). Z-scores were consistently lower than expected for the normative population by quantile-quantile plot.
CONCLUSIONS: Diminished FEV1, and to a lesser extent FVC, is found in a large majority of this population, consistent with an established body of evidence that loss of lung function begins early in life for most, if not all, children with CF.