Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017
Risk Factors for Epilepsy Recurrence after Revascularization in Pediatric Patients with Moyamoya Disease.
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Ma Yonggang, Zhao Meng, Zhang Qian, Liu Xingju, Zhang Dong, Wang Shuo, Zhang Yan, Li Maogui, Zhao Jizong
Аннотация
OBJECTIVE: We aimed to explore the risk factors of seizure recurrence and the optimal surgical procedure for epileptic pediatric patients with moyamoya disease (MMD).
METHODS: We reviewed 696 consecutive patients with MMD admitted to our hospital from 2009 to 2015. Pediatric patients with MMD who had seizures before revascularization were identified. We summarized the characteristics of seizures in pediatric patients with MMD and analyzed the predictive factors of recurrent seizure events.
RESULTS: We identified 28 pediatric patients with MMD who had seizures before revascularization. During follow-up (median 42 months), 7 patients (25.0%) experienced recurrent seizures. In the multivariate analysis, the duration of epilepsy was an independent predictor for postoperative seizure recurrences (odds ratio 3.84, 95% confidence interval 1.54-24.34; P = .035). The 2 common surgical modalities of MMD (direct and indirect bypass) had no significant difference in future seizure prevention in pediatric patients with MMD with epilepsy.
CONCLUSIONS: We identified the duration of epilepsy as an independent risk factor for recurrent seizure after revascularization in pediatric patients with MMD.
METHODS: We reviewed 696 consecutive patients with MMD admitted to our hospital from 2009 to 2015. Pediatric patients with MMD who had seizures before revascularization were identified. We summarized the characteristics of seizures in pediatric patients with MMD and analyzed the predictive factors of recurrent seizure events.
RESULTS: We identified 28 pediatric patients with MMD who had seizures before revascularization. During follow-up (median 42 months), 7 patients (25.0%) experienced recurrent seizures. In the multivariate analysis, the duration of epilepsy was an independent predictor for postoperative seizure recurrences (odds ratio 3.84, 95% confidence interval 1.54-24.34; P = .035). The 2 common surgical modalities of MMD (direct and indirect bypass) had no significant difference in future seizure prevention in pediatric patients with MMD with epilepsy.
CONCLUSIONS: We identified the duration of epilepsy as an independent risk factor for recurrent seizure after revascularization in pediatric patients with MMD.
Предметные рубрики MeSH
AdolescentAge FactorsAngiography, Digital SubtractionCerebral AngiographyChildChild, PreschoolComputed Tomography AngiographyElectroencephalographyEpilepsyFemaleHumansLogistic ModelsMagnetic Resonance AngiographyMaleMoyamoya DiseaseMultivariate AnalysisNeurosurgical ProceduresOdds RatioRecurrenceRetrospective StudiesRisk FactorsTime FactorsTreatment Outcome